Promoter methylation, transcription, and retrotransposition of LINE-1 in colorectal adenomas and adenocarcinomas

Promoter methylation, transcription, and retrotransposition of LINE-1 in colorectal adenomas and adenocarcinomas

Abstract Background The methylation of the CpG islands of the LINE-1 promoter is a tight control mechanism on the function of mobile elements. However, simultaneous quantification of promoter methylation and transcription of LINE-1 has not been performed in progressive stages of colorectal cancer. I...

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Bibliographic Details
Main Authors: Milad Shademan, Khadijeh Zare, Morteza Zahedi, Hooman Mosannen Mozaffari, Hadi Bagheri Hosseini, Kamran Ghaffarzadegan, Ladan Goshayeshi, Hesam Dehghani
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cancer Cell International
Subjects:
LINE-1
Colorectal adenoma
Colorectal adenocarcinoma
Methylation
Retrotransposition
Insertion
Online Access:http://link.springer.com/article/10.1186/s12935-020-01511-5

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http://link.springer.com/article/10.1186/s12935-020-01511-5

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