Cleavage of Dicer protein by I7 protease during vaccinia virus infection.

Dicer is the key component in the miRNA pathway. Degradation of Dicer protein is facilitated during vaccinia virus (VV) infection. A C-terminal cleaved product of Dicer protein was detected in the presence of MG132 during VV infection. Thus, it is possible that Dicer protein is cleaved by a viral pr...

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Bibliographic Details
Main Authors: Jhih-Si Chen, Hui-Chun Li, Shu-I Lin, Chee-Hing Yang, Wan-Yu Chien, Ciao-Ling Syu, Shih-Yen Lo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4376780?pdf=render