Conservation of transcription factor binding specificities across 600 million years of bilateria evolution

Conservation of transcription factor binding specificities across 600 million years of bilateria evolution

Divergent morphology of species has largely been ascribed to genetic differences in the tissue-specific expression of proteins, which could be achieved by divergence in cis-regulatory elements or by altering the binding specificity of transcription factors (TFs). The relative importance of the latte...

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Bibliographic Details
Main Authors: Kazuhiro R Nitta, Arttu Jolma, Yimeng Yin, Ekaterina Morgunova, Teemu Kivioja, Junaid Akhtar, Korneel Hens, Jarkko Toivonen, Bart Deplancke, Eileen E M Furlong, Jussi Taipale
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
transcription factor
evolutionary conservation
DNA binding specificity
HT-SELEX
Online Access:https://elifesciences.org/articles/04837

Internet

https://elifesciences.org/articles/04837

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