When MINMOD Artifactually Interprets Strong Insulin Secretion as Weak Insulin Action

When MINMOD Artifactually Interprets Strong Insulin Secretion as Weak Insulin Action

We address a problem with the Bergman-Cobelli Minimal Model, which has been used for 40 years to estimate SI during an intravenous glucose tolerance test (IVGTT). During the IVGTT blood glucose and insulin concentrations are measured in response to an acute intravenous glucose load. Insulin secretio...

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Bibliographic Details
Main Authors: Joon Ha, Ranganath Muniyappa, Arthur S. Sherman, Michael J. Quon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Physiology
Subjects:
minimal model
hyperinsulinemic euglycemic clamp
insulin resistance
racial disparities
insulin secretion
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.601894/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.601894/full

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