Early Dysfunction of Substantia Nigra Dopamine Neurons in the ParkinQ311X Mouse

Early Dysfunction of Substantia Nigra Dopamine Neurons in the ParkinQ311X Mouse

Mutations in the <i>PARK2</i> gene encoding the protein parkin cause autosomal recessive juvenile parkinsonism (ARJP), a neurodegenerative disease characterized by early dysfunction and loss of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). No therapy is currently ava...

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Bibliographic Details
Main Authors: Maria Regoni, Letizia Zanetti, Stefano Comai, Daniela Mercatelli, Salvatore Novello, Federica Albanese, Laura Croci, Gian Giacomo Consalez, Andrea Ciammola, Flavia Valtorta, Michele Morari, Jenny Sassone
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomedicines
Subjects:
Parkinson’s disease
dopaminergic neurons
parkinQ311X mouse
early dysfunction
mitochondria
cytoplasmic vacuolization
Online Access:https://www.mdpi.com/2227-9059/9/5/514

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https://www.mdpi.com/2227-9059/9/5/514

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