KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma

KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma

Abstract Background The platinum-based chemotherapy is the first-line regimen for the treatment of Non-small cell lung cancer (NSCLC). However, the therapeutic efficiency is largely limited by tenacious chemo-insensitivity that results in inferior prognosis in a cohort of patients. It has been known...

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Bibliographic Details
Main Authors: Boshi Wang, Tiantian Jing, Weilin Jin, Jinnan Chen, Chengsi Wu, Mingrong Wang, Yizhen Liu
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
KIAA1522
Lung adenocarcinoma
NFκB
Chemoresistance
Platinum-based chemotherapy
Online Access:http://link.springer.com/article/10.1186/s13046-020-01684-x

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http://link.springer.com/article/10.1186/s13046-020-01684-x

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