Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis

Novel pyrazolo[3,4-d]pyrimidines: design, synthesis, anticancer activity, dual EGFR/ErbB2 receptor tyrosine kinases inhibitory activity, effects on cell cycle profile and caspase-3-mediated apoptosis

A series of novel pyrazolo[3,4-d]pyrimidines was synthesised. Twelve synthesised compounds were evaluated for their anticancer activity against 60 human tumour cell lines by NCI (USA). Compound 7d proved prominent anticancer activity. It showed 1.6-fold more potent anti-proliferative activity agains...

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Bibliographic Details
Main Authors: Mai Maher, Asmaa E. Kassab, Ashraf F. Zaher, Zeinab Mahmoud
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
pyrazolo[3,4-d]pyrimidines
design
synthesis
anticancer activity
egfr
erbb2
caspase-3
cell cycle arrest profile
apoptosis
Online Access:http://dx.doi.org/10.1080/14756366.2018.1564046

Internet

http://dx.doi.org/10.1080/14756366.2018.1564046

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