IL-1β receptor antagonist (IL-1Ra) combined with autophagy inducer (TAT-Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes

IL-1β receptor antagonist (IL-1Ra) combined with autophagy inducer (TAT-Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes

Abstract Background Autophagy induction is an effective approach for OA therapy. IL-1β is one of the major inflammatory cytokines linked to OA pathological progression, and its receptor blockade interrupts OA cartilage destruction. The objective of this study was to decipher the link between autopha...

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Bibliographic Details
Main Authors: Fen Wang, Jijie Liu, Xiaolei Chen, Xinpeng Zheng, Ning Qu, Bing Zhang, Chun Xia
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Arthritis Research & Therapy
Subjects:
IL-1β
IL-1Ra
Autophagy
ECM
OA chondrocytes
Rat OA model
Online Access:http://link.springer.com/article/10.1186/s13075-019-1952-5

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http://link.springer.com/article/10.1186/s13075-019-1952-5

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