Mechanistic and Structural Studies of Protein-Only RNase P Compared to Ribonucleoproteins Reveal the Two Faces of the Same Enzymatic Activity

Mechanistic and Structural Studies of Protein-Only RNase P Compared to Ribonucleoproteins Reveal the Two Faces of the Same Enzymatic Activity

RNase P, the essential activity that performs the 5′ maturation of tRNA precursors, can be achieved either by ribonucleoproteins containing a ribozyme present in the three domains of life or by protein-only enzymes called protein-only RNase P (PRORP) that occur in eukaryote nuclei and organelles. A...

Full description

Bibliographic Details
Main Authors: Cédric Schelcher, Claude Sauter, Philippe Giegé
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Biomolecules
Subjects:
tRNA biogenesis
RNase P
PRORP
crystal structures
kinetic analyses
Online Access:http://www.mdpi.com/2218-273X/6/3/30

Internet

http://www.mdpi.com/2218-273X/6/3/30

Similar Items