Post-translational modifications of EZH2 in cancer
Abstract Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients. Post-translational modifications (PTMs) are impo...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-12-01
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Series: | Cell & Bioscience |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13578-020-00505-0 |