Post-translational modifications of EZH2 in cancer

Post-translational modifications of EZH2 in cancer

Abstract Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients. Post-translational modifications (PTMs) are impo...

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Bibliographic Details
Main Authors: Zhongwei Li, Minle Li, Diandian Wang, Pingfu Hou, Xintian Chen, Sufang Chu, Dafei Chai, Junnian Zheng, Jin Bai
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Cell & Bioscience
Subjects:
EZH2
Post-translational modification
Crosstalk
Cancer therapy
Online Access:https://doi.org/10.1186/s13578-020-00505-0

Internet

https://doi.org/10.1186/s13578-020-00505-0

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