STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma

STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma

Lung cancer is the second leading cause of cancer death worldwide and is strongly associated with cisplatin resistance. The transcription factor signal transducer and activator of transcription 3 (STAT3) is constitutively activated in cancer cells and coordinates critical cellular processes as survi...

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Bibliographic Details
Main Authors: Ana Paula Morelli, Tharcísio Citrângulo Tortelli, Jr, Mariana Camargo Silva Mancini, Isadora Carolina Betim Pavan, Luiz Guilherme Salvino Silva, Matheus Brandemarte Severino, Daniela Campos Granato, Nathalie Fortes Pestana, Luis Gustavo Saboia Ponte, Guilherme Francisco Peruca, Bianca Alves Pauletti, Daniel Francisco Guimarães dos Santos, Jr, Leandro Pereira de Moura, Rosângela Maria Neves Bezerra, Adriana Franco Paes Leme, Roger Chammas, Fernando Moreira Simabuco
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Lung cancer
Cisplatin
Proteomics
STAT3
mTOR
Rapamycin
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000683

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http://www.sciencedirect.com/science/article/pii/S1476558621000683

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