Significance and challenges of stereoselectivity assessing methods in drug metabolism

Stereoselectivity in drug metabolism can not only influence the pharmacological activities, tolerability, safety, and bioavailability of drugs directly, but also cause different kinds of drug–drug interactions. Thus, assessing stereoselectivity in drug metabolism is of great significance for pharmac...

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Bibliographic Details
Main Authors: Zhuowei Shen, Chuang Lv, Su Zeng
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Journal of Pharmaceutical Analysis
Subjects:
NMR
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177915300216