Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
Males are less susceptible to autoimmune diseases due to immunomodulatory effects of androgen. Here the authors show that androgen receptor upregulates Aire and Aire-dependent transcription in the thymic epithelium, and that Aire is required for androgen-mediated suppression of experimental autoimmu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11350 |