An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

Male germ cells of all placental mammals express an ancient nuclear RNA binding protein of unknown function called RBMXL2. Here we find that deletion of the retrogene encoding RBMXL2 blocks spermatogenesis. Transcriptome analyses of age-matched deletion mice show that RBMXL2 controls splicing patter...

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Bibliographic Details
Main Authors: Ingrid Ehrmann, James H Crichton, Matthew R Gazzara, Katherine James, Yilei Liu, Sushma Nagaraja Grellscheid, Tomaž Curk, Dirk de Rooij, Jannetta S Steyn, Simon Cockell, Ian R Adams, Yoseph Barash, David J Elliott
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
RNA
gene expression
alternative splicing
meiosis
spermatogenesis
retrogene
Online Access:https://elifesciences.org/articles/39304

Internet

https://elifesciences.org/articles/39304

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