Skeletal muscle, but not cardiovascular function, is altered in a mouse model of autosomal recessive hypophosphatemic rickets

Skeletal muscle, but not cardiovascular function, is altered in a mouse model of autosomal recessive hypophosphatemic rickets

Autosomal recessive hypophosphatemic rickets (ARHR) is a heritable disorder characterized by hypophosphatemia, osteomalacia, and poor bone development. ARHR results from inactivating mutations in the DMP1 gene with the human phenotype being recapitulated in the Dmp1 null mouse model which displays e...

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Bibliographic Details
Main Authors: Michael J. Wacker, Chad D. Touchberry, Neerupma eSilswal, Leticia eBrotto, Chris J. Elmore, Lynda F. Bonewald, Jon eAndresen, Marco eBrotto
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Physiology
Subjects:
Osteomalacia
Sarcopenia
skeletal muscle
cardiovascular disease
cardiac muscle
DMP1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00173/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00173/full

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