Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site

Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site

Abstract Background Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of polyubiquitinated proteins and other aggregates, are associated with neurodegenerative disease independently and through interactions of...

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Bibliographic Details
Main Authors: Meenakshisundaram Balasubramaniam, Paul A. Parcon, Chhanda Bose, Ling Liu, Richard A. Jones, Martin R. Farlow, Robert E. Mrak, Steven W. Barger, W. Sue T. Griffin
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
IL-1β
GSK3β
PINK1
Alzheimer’s
Parkin
NEDD8
Online Access:https://doi.org/10.1186/s12974-019-1669-z

Internet

https://doi.org/10.1186/s12974-019-1669-z

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