Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
Abstract Background Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of polyubiquitinated proteins and other aggregates, are associated with neurodegenerative disease independently and through interactions of...
Main Authors: | Meenakshisundaram Balasubramaniam, Paul A. Parcon, Chhanda Bose, Ling Liu, Richard A. Jones, Martin R. Farlow, Robert E. Mrak, Steven W. Barger, W. Sue T. Griffin |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-12-01
|
Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12974-019-1669-z |
Similar Items
-
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
by: Chandana Kondapalli, et al.
Published: (2012-01-01) -
Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer’s Disease
by: Zhonghua Huang, et al.
Published: (2020-02-01) -
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders
by: Haiyan He, et al.
Published: (2020-05-01) -
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
by: Agne Kazlauskaite, et al.
Published: (2014-01-01) -
Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
by: Iryna Kamienieva, et al.
Published: (2021-01-01)