Resolving cellular systems by ultra-sensitive and economical single-cell transcriptome filtering

Summary: Single-cell transcriptomics suffer from sensitivity limits that restrict low abundance transcript identification, affects clustering and can hamper downstream analyses. Here, we describe Constellation sequencing (Constellation-Seq), a molecular transcriptome filter that delivers two orders...

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Bibliographic Details
Main Authors: Andres F. Vallejo, James Davies, Amit Grover, Ching-Hsuan Tsai, Robert Jepras, Marta E. Polak, Jonathan West
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221001152