Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure

Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure

BackgroundAcetaminophen (APAP) overdose is one of the major etiologies of liver failure. Hepatocyte necrosis induced by toxic metabolites of APAP can activate proinflammatory responses, including elastase-expressing neutrophils, to exacerbate liver injury. Myeloid-derived suppressor cells (MDSCs) in...

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Bibliographic Details
Main Authors: Chen-Yu Hsu, Yung-Chang Lin, Li-Yuan Chang, Sheng-Kai Huang, Chien-Hao Huang, Chan-Keng Yang, Ching-Tai Huang, Chun-Yen Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
APAP
MDSC
iNOS
cell therapy
acute liver failure
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.574839/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.574839/full

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