Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques.

Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques.

In rodent and human brains, the small GTP-binding protein Rhes is highly expressed in virtually all dopaminoceptive striatal GABAergic medium spiny neurons, as well as in large aspiny cholinergic interneurons, where it is thought to modulate dopamine-dependent signaling. Consistent with this knowled...

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Bibliographic Details
Main Authors: Francesco Napolitano, Emily Booth Warren, Sara Migliarini, Daniela Punzo, Francesco Errico, Qin Li, Marie-Laure Thiolat, Angelo Luigi Vescovi, Paolo Calabresi, Erwan Bezard, Micaela Morelli, Christine Konradi, Massimo Pasqualetti, Alessandro Usiello
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5526584?pdf=render

Internet

http://europepmc.org/articles/PMC5526584?pdf=render

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