Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling

Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling

To determine causes of apoptotic resistance, we analyzed 124 primary B cell NHL samples using BH3 profiling, a technique that measures the mitochondrial permeabilization upon exposure to synthetic BH3 peptides. Our cohort included samples from chronic lymphocytic leukemia (CLL), follicular lymphoma...

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Bibliographic Details
Main Authors: Ryan N. Rys, Claudia M. Wever, Dominique Geoffrion, Christophe Goncalves, Artin Ghassemian, Eugene Brailovski, Jeremy Ryan, Liliana Stoica, Josée Hébert, Tina Petrogiannis-Haliotis, Svetlana Dmitrienko, Saul Frenkiel, Annette Staiger, German Ott, Christian Steidl, David W. Scott, Pierre Sesques, Sonia del Rincon, Koren K. Mann, Anthony Letai, Nathalie A. Johnson
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
NHL
BCL2
MCL1
apoptosis
DLBCL
BH3 profiling
Online Access:https://www.mdpi.com/2072-6694/13/5/1002

Internet

https://www.mdpi.com/2072-6694/13/5/1002

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