Colchicine-like β-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity

Colchicine-like β-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity

<em><strong>Objective(s):</strong></em> In this study a series of novel colchicine-like β-acetamidoketones was designed and synthesized as potential tubulin inhibitors<br /><em><strong>Materials and Methods:</strong> </em>The cytotoxicity of the...

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Bibliographic Details
Main Authors: Ehsan Karimikia, Javad Behravan, Afshin Zarghi, Morteza Ghandadi, Sina Omid Malayeri, Razieh Ghodsi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-10-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Anticancer activity
Chalcone
Colchicine
Colchicine–like
Molecular docking
Tubulin polymerization
β-acetamidoketones
Online Access:http://ijbms.mums.ac.ir/article_13596_eb66ad068ef309ce9c0ae9e519d791d3.pdf

Internet

http://ijbms.mums.ac.ir/article_13596_eb66ad068ef309ce9c0ae9e519d791d3.pdf

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