Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.

Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.

BACKGROUND: Cyclosporin A (CsA) has important anti-microbial activity against parasites of the genus Leishmania, suggesting CsA-binding cyclophilins (CyPs) as potential drug targets. However, no information is available on the genetic diversity of this important protein family, and the mechanisms un...

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Bibliographic Details
Main Authors: Wai-Lok Yau, Thierry Blisnick, Jean-François Taly, Manuela Helmer-Citterich, Cordelia Schiene-Fischer, Olivier Leclercq, Jing Li, Dirk Schmidt-Arras, Miguel A Morales, Cedric Notredame, Daniel Romo, Philippe Bastin, Gerald F Späth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC2894131?pdf=render

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http://europepmc.org/articles/PMC2894131?pdf=render

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