Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity.

Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity.

Approximately 35 million people worldwide suffer from Alzheimer's disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence. AD is associated with an increase in amyloid beta (Aβ) oligomers and hyperphosphorylated tau, alo...

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Bibliographic Details
Main Authors: Wayne Chadwick, Nick Mitchell, Jenna Caroll, Yu Zhou, Sung-Soo Park, Liyun Wang, Kevin G Becker, Yongqing Zhang, Elin Lehrmann, William H Wood, Bronwen Martin, Stuart Maudsley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3124550?pdf=render

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http://europepmc.org/articles/PMC3124550?pdf=render

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