PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Mutations in PTEN-induced putative kinase 1 (PINK1) and parkin cause autosomal-recessive Parkinson’s disease through a common pathway involving mitochondrial quality control. Parkin inactivation leads to accumulation of the parkin interacting substrate (PARIS, ZNF746) that plays an important role in...

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Bibliographic Details
Main Authors: Yunjong Lee, Daniel A. Stevens, Sung-Ung Kang, Haisong Jiang, Yun-Il Lee, Han Seok Ko, Leslie A. Scarffe, George E. Umanah, Hojin Kang, Sangwoo Ham, Tae-In Kam, Kathleen Allen, Saurav Brahmachari, Jungwoo Wren Kim, Stewart Neifert, Seung Pil Yun, Fabienne C. Fiesel, Wolfdieter Springer, Valina L. Dawson, Joo-Ho Shin, Ted M. Dawson
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
parkin
PINK1
PARIS
ZNF746
ubiquitin
PGC-1α
Parkinson’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716318125

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http://www.sciencedirect.com/science/article/pii/S2211124716318125

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