PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle

PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle

Nearly 100 years ago, Otto Warburg investigated the metabolism of growing tissues and discovered that tumors reprogram their metabolism. It is poorly understood whether and how hypertrophying muscle, another growing tissue, reprograms its metabolism too. Here, we studied pyruvate kinase muscle (PKM)...

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Bibliographic Details
Main Authors: Sander A. J. Verbrugge, Sebastian Gehlert, Lian E. M. Stadhouders, Daniel Jacko, Thorben Aussieker, Gerard M. J. de Wit, Ilse S. P. Vogel, Carla Offringa, Martin Schönfelder, Richard T. Jaspers, Henning Wackerhage
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
Warburg effect
pyruvate kinase
insulin-like growth factor 1
glycolysis
skeletal muscle
hypertrophy
Online Access:https://www.mdpi.com/1422-0067/21/19/7062

Internet

https://www.mdpi.com/1422-0067/21/19/7062

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