Low Hydrophobic Mismatch Scores Calculated for HLA-A/B/DR/DQ Loci Improve Kidney Allograft Survival

Low Hydrophobic Mismatch Scores Calculated for HLA-A/B/DR/DQ Loci Improve Kidney Allograft Survival

We evaluated the impact of human leukocyte antigen (HLA) disparity (immunogenicity; IM) on long-term kidney allograft survival. The IM was quantified based on physicochemical properties of the polymorphic linear donor/recipient HLA amino acids (the Cambridge algorithm) as a hydrophobic, electrostati...

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Bibliographic Details
Main Authors: Dulat Bekbolsynov, Beata Mierzejewska, Jadwiga Borucka, Robert S. Liwski, Anna L. Greenshields, Joshua Breidenbach, Bradley Gehring, Shravan Leonard-Murali, Sadik A. Khuder, Michael Rees, Robert C. Green, Stanislaw M. Stepkowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
kidney transplantation
kidney allocation
transplant survival
human leukocyte antigen (HLA)
HLA mismatch
immunogenicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.580752/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.580752/full

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