Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpression

Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpression

Gamma-ray emitting 111In, which is extensively used for imaging, is also a source of short-range Auger electrons (AE). While exhibiting negligible effect outside cells, these AE become highly toxic near DNA within the cell nucleus. Therefore, these radionuclides can be used as a therapeutic anticanc...

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Bibliographic Details
Main Authors: Andrey A. Rosenkranz, Tatiana A. Slastnikova, Tatiana A. Karmakova, Maria S. Vorontsova, Natalia B. Morozova, Vasiliy M. Petriev, Alexey S. Abrosimov, Yuri V. Khramtsov, Tatiana N. Lupanova, Alexey V. Ulasov, Raisa I. Yakubovskaya, Georgii P. Georgiev, Alexander S. Sobolev
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
modular nanotransporters
drug delivery
intracellular transport
bladder cancer
radionuclide therapy
Auger electron emitter
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01331/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01331/full

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