Unifying the mechanism of mitotic exit control in a spatiotemporal logical model.

The transition from mitosis into the first gap phase of the cell cycle in budding yeast is controlled by the Mitotic Exit Network (MEN). The network interprets spatiotemporal cues about the progression of mitosis and ensures that release of Cdc14 phosphatase occurs only after completion of key mitot...

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Bibliographic Details
Main Authors: Rowan S M Howell, Cinzia Klemm, Peter H Thorpe, Attila Csikász-Nagy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000917