Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors

Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors

Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells developing from myeloid progenitors, which are enriched in pathological conditions such as cancer, and are known to inhibit the functions of effector T cells. During aging, several changes occ...

Full description

Bibliographic Details
Main Authors: Sara Magri, Elena Masetto, Samantha Solito, Samuela Francescato, Elisa Belluzzi, Assunta Pozzuoli, Antonio Berizzi, Pietro Ruggieri, Susanna Mandruzzato
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Immunity & Ageing
Subjects:
MDSCs
Aging
Immunosuppression
Online Access:http://link.springer.com/article/10.1186/s12979-020-00199-5

Internet

http://link.springer.com/article/10.1186/s12979-020-00199-5

Similar Items