Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia.

Dihydrofolate-Reductase Mutations in Plasmodium knowlesi Appear Unrelated to Selective Drug Pressure from Putative Human-To-Human Transmission in Sabah, Malaysia.

BACKGROUND:Malaria caused by zoonotic Plasmodium knowlesi is an emerging threat in Eastern Malaysia. Despite demonstrated vector competency, it is unknown whether human-to-human (H-H) transmission is occurring naturally. We sought evidence of drug selection pressure from the antimalarial sulfadoxine...

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Bibliographic Details
Main Authors: Matthew J Grigg, Bridget E Barber, Jutta Marfurt, Mallika Imwong, Timothy William, Elspeth Bird, Kim A Piera, Ammar Aziz, Usa Boonyuen, Christopher J Drakeley, Jonathan Cox, Nicholas J White, Qin Cheng, Tsin W Yeo, Sarah Auburn, Nicholas M Anstey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4773021?pdf=render

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http://europepmc.org/articles/PMC4773021?pdf=render

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