Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation.

Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation.

Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop metastatic disease, which is almost invariably lethal. However, our understanding of pathways that drive aggressive behavior of MIBC is incomplete. Members of the FOXA subfamily of transcription factors are implicated i...

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Bibliographic Details
Main Authors: David J DeGraff, Peter E Clark, Justin M Cates, Hironobu Yamashita, Victoria L Robinson, Xiuping Yu, Mark E Smolkin, Sam S Chang, Michael S Cookson, Mary K Herrick, Shahrokh F Shariat, Gary D Steinberg, Henry F Frierson, Xue-Ru Wu, Dan Theodorescu, Robert J Matusik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3349679?pdf=render

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http://europepmc.org/articles/PMC3349679?pdf=render

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