PDL1 Fusion Protein Protects Against Experimental Cerebral Malaria via Repressing Over-Reactive CD8+ T Cell Responses

PDL1 Fusion Protein Protects Against Experimental Cerebral Malaria via Repressing Over-Reactive CD8+ T Cell Responses

Cerebral malaria (CM), mainly caused by Plasmodium falciparum (P. f.), is one of the most lethal complications of severe malaria. As immunopathology mediated by brain-infiltrating CD8+ T cells is the major pathogenesis of CM, there is no safe and efficient treatment clinically focused on CD8+ T cell...

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Bibliographic Details
Main Authors: Jun Wang, Yue Li, Yan Shen, Jiao Liang, Yinghui Li, Yuxiao Huang, Xuewu Liu, Dongbo Jiang, Shuya Yang, Ya Zhao, Kun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
PD-1/PDL1
experimental cerebral malaria
macrophage
CD8+ T cell
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03157/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03157/full

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