Dopamine Autoxidation Is Controlled by Acidic pH

We studied the reaction mechanism of dopamine autoxidation using quantum chemical methods. Unlike other biogenic amines important in the central nervous system, dopamine and noradrenaline are capable of undergoing a non-enzymatic autoxidative reaction giving rise to a superoxide anion that further d...

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Bibliographic Details
Main Authors: Nejc Umek, Blaž Geršak, Neli Vintar, Maja Šoštarič, Janez Mavri
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
pH
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00467/full