Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells

Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells

Hypoxia, angiogenesis, and immunosuppression have been proposed to be interrelated events that fuel tumor progression and impair the clinical effectiveness of anti-tumor therapies. Here we present new mechanistic data highlighting the role of hypoxia in fine-tuning CD8 T cell exhaustion in vitro, in...

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Bibliographic Details
Main Authors: Nadia Bannoud, Tomás Dalotto-Moreno, Lucía Kindgard, Pablo A. García, Ada G. Blidner, Karina V. Mariño, Gabriel A. Rabinovich, Diego O. Croci
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
Hypoxia
CD8 T cell exhaustion
immunosuppression
VEGF-A
anti cancer agents
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.660944/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.660944/full

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