Downregulation of the <i>Glo1</i> Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats

Downregulation of the <i>Glo1</i> Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats

Methylglyoxal (MG), a potent precursor of advanced glycation end-products (AGE), is increased in metabolic disorders such as diabetes and obesity. MG and other dicarbonyl metabolites are detoxified by the glyoxalase system in which glyoxalase 1, coded by the <i>Glo1</i> gene, serves as t...

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Bibliographic Details
Main Authors: Jan Šilhavý, Hana Malínská, Martina Hüttl, Irena Marková, Olena Oliyarnyk, Petr Mlejnek, Miroslava Šimáková, František Liška, Ludmila Kazdová, Radka Moravcová, Jiří Novotný, Michal Pravenec
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antioxidants
Subjects:
<i>Glo1</i> gene knockdown
spontaneously hypertensive rat
methylglyoxal
heart
adipose tissue
insulin resistance
Online Access:https://www.mdpi.com/2076-3921/9/12/1179

Internet

https://www.mdpi.com/2076-3921/9/12/1179

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