Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment

Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment

The role of neutrophils in tumor progression has become in recent years a subject of growing interest. Tumor-associated neutrophils (TANs), which constitute an important portion of the tumor microenvironment, promote immunosuppression in advanced tumors by modulating the proliferation, activation an...

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Bibliographic Details
Main Authors: Janna Michaeli, Merav E. Shaul, Inbal Mishalian, Avi-Hai Hovav, Liran Levy, Lidia Zolotriov, Zvi Granot, Zvi G. Fridlender
Format: Article
Language:English
Published: Taylor & Francis Group 2017-11-01
Series:OncoImmunology
Subjects:
activation
apoptosis
cd8 cytotoxic t-cell
immunotolerance
lung cancer
tumor-associated neutrophils
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1356965

Internet

http://dx.doi.org/10.1080/2162402X.2017.1356965

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