Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey--a meta-analysis of three independent studies.

Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey--a meta-analysis of three independent studies.

Genome-wide association studies (GWASs) have identified a large number of variants (SNPs) associating with an increased risk of coronary artery disease (CAD). Recently, the CARDIoGRAM consortium published a GWAS based on the largest study population so far. They successfully replicated twelve alread...

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Bibliographic Details
Main Authors: Jussi A Hernesniemi, Ilkka Seppälä, Leo-Pekka Lyytikäinen, Nina Mononen, Niku Oksala, Nina Hutri-Kähönen, Markus Juonala, Leena Taittonen, Erin N Smith, Nicholas J Schork, Wei Chen, Sathanur R Srinivasan, Gerald S Berenson, Sarah S Murray, Tomi Laitinen, Antti Jula, Johannes Kettunen, Samuli Ripatti, Reijo Laaksonen, Jorma Viikari, Mika Kähönen, Olli T Raitakari, Terho Lehtimäki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3266236?pdf=render

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http://europepmc.org/articles/PMC3266236?pdf=render

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