Structure-Based Modeling of Complement C4 Mediated Neutralization of Adenovirus

Adenovirus (AdV) infection elicits a strong immune response with the production of neutralizing antibodies and opsonization by complement and coagulation factors. One anti-hexon neutralizing antibody, called 9C12, is known to activate the complement cascade, resulting in the deposition of complement...

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Bibliographic Details
Main Authors: Corey C. Emerson, Phoebe L. Stewart
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/13/1/111