Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

TRIF is an important adaptor protein for mediating Toll-like receptor (TLR) 3 and TLR4 signaling. Here the authors show that the deubiquitinating enzymes USP19, as well as the E3 ubiquitin ligase complex Cullin-3-Rbx1-KCTD10, modulates TRIF K523 ubiquitination and thereby TRIF recruitment to TLR3/4...

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Bibliographic Details
Main Authors: Xin Wu, Caoqi Lei, Tian Xia, Xuan Zhong, Qing Yang, Hong-Bing Shu
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12145-1