Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

TRIF is an important adaptor protein for mediating Toll-like receptor (TLR) 3 and TLR4 signaling. Here the authors show that the deubiquitinating enzymes USP19, as well as the E3 ubiquitin ligase complex Cullin-3-Rbx1-KCTD10, modulates TRIF K523 ubiquitination and thereby TRIF recruitment to TLR3/4...

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Main Authors: Xin Wu, Caoqi Lei, Tian Xia, Xuan Zhong, Qing Yang, Hong-Bing Shu
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12145-1
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spelling doaj-12696a5c84fc4384b0e426fdaa8451f92021-05-11T12:11:01ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-12145-1Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitinationXin Wu0Caoqi Lei1Tian Xia2Xuan Zhong3Qing Yang4Hong-Bing Shu5Department of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan UniversityDepartment of Cell Biology, College of Life Sciences, Wuhan UniversityDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan UniversityDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan UniversityDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan UniversityDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan UniversityTRIF is an important adaptor protein for mediating Toll-like receptor (TLR) 3 and TLR4 signaling. Here the authors show that the deubiquitinating enzymes USP19, as well as the E3 ubiquitin ligase complex Cullin-3-Rbx1-KCTD10, modulates TRIF K523 ubiquitination and thereby TRIF recruitment to TLR3/4 to control innate immunity.https://doi.org/10.1038/s41467-019-12145-1
collection DOAJ
language English
format Article
sources DOAJ
author Xin Wu
Caoqi Lei
Tian Xia
Xuan Zhong
Qing Yang
Hong-Bing Shu
spellingShingle Xin Wu
Caoqi Lei
Tian Xia
Xuan Zhong
Qing Yang
Hong-Bing Shu
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
Nature Communications
author_facet Xin Wu
Caoqi Lei
Tian Xia
Xuan Zhong
Qing Yang
Hong-Bing Shu
author_sort Xin Wu
title Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_short Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_full Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_fullStr Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_full_unstemmed Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_sort regulation of trif-mediated innate immune response by k27-linked polyubiquitination and deubiquitination
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description TRIF is an important adaptor protein for mediating Toll-like receptor (TLR) 3 and TLR4 signaling. Here the authors show that the deubiquitinating enzymes USP19, as well as the E3 ubiquitin ligase complex Cullin-3-Rbx1-KCTD10, modulates TRIF K523 ubiquitination and thereby TRIF recruitment to TLR3/4 to control innate immunity.
url https://doi.org/10.1038/s41467-019-12145-1
work_keys_str_mv AT xinwu regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT caoqilei regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT tianxia regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT xuanzhong regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT qingyang regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT hongbingshu regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
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