HIF1α overexpression enhances diabetic wound closure in high glucose and low oxygen conditions by promoting adipose-derived stem cell paracrine function and survival

HIF1α overexpression enhances diabetic wound closure in high glucose and low oxygen conditions by promoting adipose-derived stem cell paracrine function and survival

Abstract Background Adipose-derived stem cell (ADSC) transplantation is a promising strategy to promote wound healing because of the paracrine function of stem cells. However, glucose-associated effects on stem cell paracrine function and survival contribute to impaired wound closure in patients wit...

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Bibliographic Details
Main Authors: Jin Xu, Xiaoyu Liu, Feng Zhao, Ying Zhang, Zhe Wang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Stem Cell Research & Therapy
Subjects:
Hypoxia-inducible factor 1α
Adipose-derived stem cells
Wound healing
High glucose
Reactive oxygen species
Mice
Online Access:http://link.springer.com/article/10.1186/s13287-020-01654-2

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http://link.springer.com/article/10.1186/s13287-020-01654-2

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