Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease
Background. Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson’s disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS. Objective. To delineate NMS in FDR of patients with different clinical types of PD. Methods. A total of 98 PD...
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doaj-127044a12444497ead572df8002fd6bd2020-11-24T22:02:05ZengHindawi LimitedParkinson's Disease2090-80832042-00802019-01-01201910.1155/2019/16541611654161Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s DiseaseJiang-bing Liu0Jun-ling Leng1Ying-ge Wang2Yu Zhang3Tie-yu Tang4Li-hong Tao5Xin-jiang Zhang6Chun-feng Liu7Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaEmergency Department, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaBackground. Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson’s disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS. Objective. To delineate NMS in FDR of patients with different clinical types of PD. Methods. A total of 98 PD probands were recruited; 256 siblings of them were enrolled in the FDR group. Various scales were used to assess NMS, including depression, anxiety, cognitive impairment, insomnia, constipation, excessive daytime sleepiness, rapid eye movement sleep behavior disorder (RBD), and restless legs syndrome (RLS). The incidences of NMS were further compared between the FDR groups of PD with different types. Results. The FDR of early-onset PD (EOP) showed a higher incidence of moderate to severe depression (OR = 4.08; 95% CI: 1.12–14.92; P=0.033), anxiety (OR = 4.22; 95% CI: 1.87–9.52; P=0.001), and excessive daytime sleepiness (OR = 3.40; 95% CI: 1.00–11.48; P=0.049) than the FDR of late-onset PD (LOP). It was also found that RBD (OR = 11.65; 95% CI: 3.82–35.54; P<0.001), constipation (OR = 4.94; 95% CI: 1.85–13.21; P=0.001), sleep disorders (OR = 4.51; 95% CI: 1.73–11.78; P=0.002), cognitive impairment (OR = 3.55; 95% CI: 1.62–7.77; P=0.002), and anxiety (OR = 2.49; 95% CI: 1.32–4.71; P=0.005) were more frequent in FDR of tremor-dominant PD (TDP) than in FDR of non-tremor-dominant PD (NTDP). Conclusions. The siblings of patients with EOP and TDP have more NMS, presuming that they have a higher risk in the PD prodromal stage. Whether they have a greater possibility to progress into PD requires further investigation.http://dx.doi.org/10.1155/2019/1654161 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiang-bing Liu Jun-ling Leng Ying-ge Wang Yu Zhang Tie-yu Tang Li-hong Tao Xin-jiang Zhang Chun-feng Liu |
spellingShingle |
Jiang-bing Liu Jun-ling Leng Ying-ge Wang Yu Zhang Tie-yu Tang Li-hong Tao Xin-jiang Zhang Chun-feng Liu Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease Parkinson's Disease |
author_facet |
Jiang-bing Liu Jun-ling Leng Ying-ge Wang Yu Zhang Tie-yu Tang Li-hong Tao Xin-jiang Zhang Chun-feng Liu |
author_sort |
Jiang-bing Liu |
title |
Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease |
title_short |
Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease |
title_full |
Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease |
title_fullStr |
Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease |
title_full_unstemmed |
Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease |
title_sort |
investigation of nonmotor symptoms in first-degree relatives of patients with different clinical types of parkinson’s disease |
publisher |
Hindawi Limited |
series |
Parkinson's Disease |
issn |
2090-8083 2042-0080 |
publishDate |
2019-01-01 |
description |
Background. Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson’s disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS. Objective. To delineate NMS in FDR of patients with different clinical types of PD. Methods. A total of 98 PD probands were recruited; 256 siblings of them were enrolled in the FDR group. Various scales were used to assess NMS, including depression, anxiety, cognitive impairment, insomnia, constipation, excessive daytime sleepiness, rapid eye movement sleep behavior disorder (RBD), and restless legs syndrome (RLS). The incidences of NMS were further compared between the FDR groups of PD with different types. Results. The FDR of early-onset PD (EOP) showed a higher incidence of moderate to severe depression (OR = 4.08; 95% CI: 1.12–14.92; P=0.033), anxiety (OR = 4.22; 95% CI: 1.87–9.52; P=0.001), and excessive daytime sleepiness (OR = 3.40; 95% CI: 1.00–11.48; P=0.049) than the FDR of late-onset PD (LOP). It was also found that RBD (OR = 11.65; 95% CI: 3.82–35.54; P<0.001), constipation (OR = 4.94; 95% CI: 1.85–13.21; P=0.001), sleep disorders (OR = 4.51; 95% CI: 1.73–11.78; P=0.002), cognitive impairment (OR = 3.55; 95% CI: 1.62–7.77; P=0.002), and anxiety (OR = 2.49; 95% CI: 1.32–4.71; P=0.005) were more frequent in FDR of tremor-dominant PD (TDP) than in FDR of non-tremor-dominant PD (NTDP). Conclusions. The siblings of patients with EOP and TDP have more NMS, presuming that they have a higher risk in the PD prodromal stage. Whether they have a greater possibility to progress into PD requires further investigation. |
url |
http://dx.doi.org/10.1155/2019/1654161 |
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