Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease

Background. Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson’s disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS. Objective. To delineate NMS in FDR of patients with different clinical types of PD. Methods. A total of 98 PD...

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Main Authors: Jiang-bing Liu, Jun-ling Leng, Ying-ge Wang, Yu Zhang, Tie-yu Tang, Li-hong Tao, Xin-jiang Zhang, Chun-feng Liu
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.1155/2019/1654161
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spelling doaj-127044a12444497ead572df8002fd6bd2020-11-24T22:02:05ZengHindawi LimitedParkinson's Disease2090-80832042-00802019-01-01201910.1155/2019/16541611654161Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s DiseaseJiang-bing Liu0Jun-ling Leng1Ying-ge Wang2Yu Zhang3Tie-yu Tang4Li-hong Tao5Xin-jiang Zhang6Chun-feng Liu7Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaEmergency Department, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaBackground. Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson’s disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS. Objective. To delineate NMS in FDR of patients with different clinical types of PD. Methods. A total of 98 PD probands were recruited; 256 siblings of them were enrolled in the FDR group. Various scales were used to assess NMS, including depression, anxiety, cognitive impairment, insomnia, constipation, excessive daytime sleepiness, rapid eye movement sleep behavior disorder (RBD), and restless legs syndrome (RLS). The incidences of NMS were further compared between the FDR groups of PD with different types. Results. The FDR of early-onset PD (EOP) showed a higher incidence of moderate to severe depression (OR = 4.08; 95% CI: 1.12–14.92; P=0.033), anxiety (OR = 4.22; 95% CI: 1.87–9.52; P=0.001), and excessive daytime sleepiness (OR = 3.40; 95% CI: 1.00–11.48; P=0.049) than the FDR of late-onset PD (LOP). It was also found that RBD (OR = 11.65; 95% CI: 3.82–35.54; P<0.001), constipation (OR = 4.94; 95% CI: 1.85–13.21; P=0.001), sleep disorders (OR = 4.51; 95% CI: 1.73–11.78; P=0.002), cognitive impairment (OR = 3.55; 95% CI: 1.62–7.77; P=0.002), and anxiety (OR = 2.49; 95% CI: 1.32–4.71; P=0.005) were more frequent in FDR of tremor-dominant PD (TDP) than in FDR of non-tremor-dominant PD (NTDP). Conclusions. The siblings of patients with EOP and TDP have more NMS, presuming that they have a higher risk in the PD prodromal stage. Whether they have a greater possibility to progress into PD requires further investigation.http://dx.doi.org/10.1155/2019/1654161
collection DOAJ
language English
format Article
sources DOAJ
author Jiang-bing Liu
Jun-ling Leng
Ying-ge Wang
Yu Zhang
Tie-yu Tang
Li-hong Tao
Xin-jiang Zhang
Chun-feng Liu
spellingShingle Jiang-bing Liu
Jun-ling Leng
Ying-ge Wang
Yu Zhang
Tie-yu Tang
Li-hong Tao
Xin-jiang Zhang
Chun-feng Liu
Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease
Parkinson's Disease
author_facet Jiang-bing Liu
Jun-ling Leng
Ying-ge Wang
Yu Zhang
Tie-yu Tang
Li-hong Tao
Xin-jiang Zhang
Chun-feng Liu
author_sort Jiang-bing Liu
title Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease
title_short Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease
title_full Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease
title_fullStr Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease
title_full_unstemmed Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson’s Disease
title_sort investigation of nonmotor symptoms in first-degree relatives of patients with different clinical types of parkinson’s disease
publisher Hindawi Limited
series Parkinson's Disease
issn 2090-8083
2042-0080
publishDate 2019-01-01
description Background. Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson’s disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS. Objective. To delineate NMS in FDR of patients with different clinical types of PD. Methods. A total of 98 PD probands were recruited; 256 siblings of them were enrolled in the FDR group. Various scales were used to assess NMS, including depression, anxiety, cognitive impairment, insomnia, constipation, excessive daytime sleepiness, rapid eye movement sleep behavior disorder (RBD), and restless legs syndrome (RLS). The incidences of NMS were further compared between the FDR groups of PD with different types. Results. The FDR of early-onset PD (EOP) showed a higher incidence of moderate to severe depression (OR = 4.08; 95% CI: 1.12–14.92; P=0.033), anxiety (OR = 4.22; 95% CI: 1.87–9.52; P=0.001), and excessive daytime sleepiness (OR = 3.40; 95% CI: 1.00–11.48; P=0.049) than the FDR of late-onset PD (LOP). It was also found that RBD (OR = 11.65; 95% CI: 3.82–35.54; P<0.001), constipation (OR = 4.94; 95% CI: 1.85–13.21; P=0.001), sleep disorders (OR = 4.51; 95% CI: 1.73–11.78; P=0.002), cognitive impairment (OR = 3.55; 95% CI: 1.62–7.77; P=0.002), and anxiety (OR = 2.49; 95% CI: 1.32–4.71; P=0.005) were more frequent in FDR of tremor-dominant PD (TDP) than in FDR of non-tremor-dominant PD (NTDP). Conclusions. The siblings of patients with EOP and TDP have more NMS, presuming that they have a higher risk in the PD prodromal stage. Whether they have a greater possibility to progress into PD requires further investigation.
url http://dx.doi.org/10.1155/2019/1654161
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