Modeling amyotrophic lateral sclerosis in pure human iPSc-derived motor neurons isolated by a novel FACS double selection technique

Modeling amyotrophic lateral sclerosis in pure human iPSc-derived motor neurons isolated by a novel FACS double selection technique

Amyotrophic lateral sclerosis (ALS) is a severe and incurable neurodegenerative disease. Human motor neurons generated from induced pluripotent stem cells (iPSc) offer new perspectives for disease modeling and drug testing in ALS. In standard iPSc-derived cultures, however, the two major phenotypic...

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Bibliographic Details
Main Authors: Diana Toli, Dorothée Buttigieg, Stéphane Blanchard, Thomas Lemonnier, Boris Lamotte d’Incamps, Sarah Bellouze, Gilbert Baillat, Delphine Bohl, Georg Haase
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Motor neuron disease
Amyotrophic lateral sclerosis (ALS)
Induced pluripotent stem cells (iPSc)
Cell death
Axon degeneration
Fluorescent-activated cell sorting (FACS)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115002296

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http://www.sciencedirect.com/science/article/pii/S0969996115002296

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