Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

Environmental enrichment has been shown to be both neuroprotective and neurorestorative in 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models of Parkinson's disease (PD). However, whether social interaction or novel physical stimulation is responsible for this recovery is controve...

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Bibliographic Details
Main Authors: Natalie R.S. Goldberg, Victoria Fields, Lacey Pflibsen, Michael F. Salvatore, Charles K. Meshul
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Dopamine
Striatum
MPTP
Social enrichment
Tyrosine hydroxylase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003998

Internet

http://www.sciencedirect.com/science/article/pii/S0969996111003998

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