Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression

Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression

Abstract Background Recent studies have shown that the classic hypoglycemic drug metformin inhibits tumor growth; however, the underlying mechanism remains unclear. We previously showed that metformin disrupts the sponge effect of long non-coding RNA MALAT1/miR-142-3p to inhibit cervical cancer cell...

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Bibliographic Details
Main Authors: Chenglai Xia, Chang Liu, Zhihong He, Yantao Cai, Jinman Chen
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Metformin
Histocompatibility complex class I-related chain a
Cervical cancer
PI3K
Cell proliferation
Online Access:http://link.springer.com/article/10.1186/s13046-020-01627-6

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http://link.springer.com/article/10.1186/s13046-020-01627-6

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