The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damage

The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damage

Efficient DNA repair is critical for cell survival following exposure to DNA topoisomerase I (Top1) inhibitors camptothecin, a nature product from which the common chemotherapeutic drugs irinotecan and topotecan are derived. The camptothecin-derived agents exert their antitumor activities by specifi...

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Bibliographic Details
Main Authors: Chao Mei, Lin Lei, Li-Ming Tan, Xiao-Jing Xu, Bai-Mei He, Chao Luo, Ji-Ye Yin, Xi Li, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Camptothecin
Single strand break repair
Chemoresistance
DNA repair
Topoisomerase I
Genomic stability
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220300652

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http://www.sciencedirect.com/science/article/pii/S0753332220300652

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