Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling

Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling

<p>Abstract</p> <p>Background</p> <p>Prolonged neutrophil survival is evident in various cardiovascular and respiratory morbidities, in hypoxic conditions <it>in-vitro</it> and in patients with obstructive sleep apnea (OSA) characterized by nightly intermitt...

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Bibliographic Details
Main Authors: Dyugovskaya Larissa, Polyakov Andrey, Cohen-Kaplan Victoria, Lavie Peretz, Lavie Lena
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Journal of Translational Medicine
Subjects:
Intermittent hypoxia
Obstructive Sleep Apnea
Neutrophil mitochondrial apoptotic pathway
Bax/Mcl-1 balance
ERK 1/2 signaling
p38MAPK signaling
Online Access:http://www.translational-medicine.com/content/10/1/211

Internet

http://www.translational-medicine.com/content/10/1/211

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