Endothelial-mesenchymal transition harnesses HSP90α-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma

Endothelial-mesenchymal transition harnesses HSP90α-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma

Abstract Background Endothelial-to-mesenchymal transition (EndoMT) can provide a source of cancer-associated fibroblasts which contribute to desmoplasia of many malignancies including pancreatic ductal adenocarcinoma (PDAC). We investigated the clinical relevance of EndoMT in PDAC, and explored its...

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Bibliographic Details
Main Authors: Chi-Shuan Fan, Li-Li Chen, Tsu-An Hsu, Chia-Chi Chen, Kee Voon Chua, Chung-Pin Li, Tze-Sing Huang
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Hematology & Oncology
Subjects:
EndoMT
Cancer-associated fibroblast
M2-type macrophage
eHSP90α
Online Access:https://doi.org/10.1186/s13045-019-0826-2

Internet

https://doi.org/10.1186/s13045-019-0826-2

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