S-nitrosylated and non-nitrosylated COX2 have differential expression and distinct subcellular localization in normal and breast cancer tissue

S-nitrosylated and non-nitrosylated COX2 have differential expression and distinct subcellular localization in normal and breast cancer tissue

Abstract Immunohistochemical (IHC) staining in breast cancer shows both gain and loss of COX2 expression with disease risk and progression. We investigated four common COX2 antibody clones and found high specificity for purified human COX2 for three clones; however, recognition of COX2 in cell lysat...

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Bibliographic Details
Main Authors: Sonali Jindal, Nathan D. Pennock, Alex Klug, Jayasri Narasimhan, Andrea Calhoun, Michelle R. Roberts, Rulla M. Tamimi, A. Heather Eliassen, Sheila Weinmann, Virginia F. Borges, Pepper Schedin
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-020-00204-6

Internet

https://doi.org/10.1038/s41523-020-00204-6

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